Product Description

Trinity® Evolution™ is an allograft of cancellous bone containing viable osteogenic cells and osteoprogenitor cells within the matrix and a demineralized bone component. Trinity Evolution offers an ideal alternative to autograft and other bone grafting options .

Adult mesenchymal stem cells (MSCs) are multipotential, capable of responding to their environment to differentiate into a variety of cells as needed. When implanted in patients, MSCs and osteoprogenitor cells do not stimulate an immune response.

Trinity Evolution is processed by the Musculoskeletal Transplant Foundation (MTF), a nonprofit organization dedicated to providing quality tissue. Every step, from donor screening to cryopreservation and pre-release testing, is designed to maximize cell health and ensure patient safety.

Ensuring quality at every step: 

  • MTF is committed to excellence in tissue quality
  • Cell health is maximized through donor criteria, processing and vapor-phase liquid nitrogen storage
  • Improved handling from consistent particle size and specific component ratios

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Indication
Trinity Evolution is an allograft intended for the treatment of musculoskeletal defects.

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Physician Benefits

Ensuring quality at every step:

  • MTF is committed to excellence in tissue quality
  • Cell health is maximized through donor criteria, processing and vapor-phase liquid nitrogen storage
  • Improved handling from consistent particle size and specific component ratios
Trinity Evolution supplies the three essential components for robust bone formation:
  • Osteoconductive scaffold
  • Verified osteoinductive potential
  • A reliable number of viable osteogenic cells retained within the cancellous matrix 

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Clinical References:
  • Rush S. Mesenchymal Stem Cell Allografting in Foot and Ankle Surgery. Foot & Ankle Specialist June 2010 Vol. 3(3):140-147. Full Text Article
  • Pountos I, Giannoudis P: Biology of Mesenchymal Stem Cells. Injury 2005 Nov; Vol. 36 Suppl. 3:S8-S12. Full Text Article
  • Barry FP, Murphy JM: Mesenchymal Stem Cells: Clinical Applications and Biological Characterization. International Journal of Biochemistry and Cell Biology 2004 Apr; Vol. 36(4):568-84. Full Text Article
  • Bonab M et al: Aging of Mesenchymal Stem Cell in Vitro. BMC Cell Biology 2006 Mar 10; Vol. 7:14. Full Text Article
  • D'Ippolito G et al: Age-Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow. Journal of Bone and Mineral Research 1999 Jul; Vol. 14(7):1115-22. Full Text Article
  • Sethe S et al: Aging of Mesenchymal Stem Cells. Ageing Research Reviews 2006 Feb; Vol. 5(1):91-116. Full Text Article
  • Stolzing A et al: Age-Related Changes in Human Bone Marrow-Derived Mesenchymal Stem Cells: Consequences for Cell Therapies. Mechanisms of Ageing and Development 2008 Mar; Vol. 129(3):163-73. Full Text Article
  • Le Blanc K et al: HLA Expression and Immunologic Properties of Differentiated and Undifferentiated Mesenchymal Stem Cells. Experimental Hematology 2003 Oct; Vol. 31(10):890-6. Full Text Article
  • Ryan JM et al: Mesenchymal Stem Cells Avoid Allogeneic Rejection. Journal of Inflammation (London) 2005 Jul 26; Vol. 2:8. Full Text Article
  • Mazur P: Freezing of Living Cells: Mechanisms and Implications. American Journal of Physiology 1984 Sep; Vol. 247(3 Pt 1):C125-42. Full Text Article

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Web Resources
  1. Musculoskeletal Transplant Foundation

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