Physician Benefits
- Osteoconductive scaffold
- Verified osteoinductive potential
- A reliable number of viable osteogenic cells retained within the cancellous matrix
Cell health is maximized through donor criteria, processing and vapor-phase liquid nitrogen storage. Improved handling from consistent particle size and specific component ratios ensures quality at every step.
Physician Support Materials
- Trinity Evolution Safety Paper (PDF 451 KB)
- Trinity Evolution Brochure (PDF 2.1MB)
- Trinity Evolution Frequently Asked Questions (PDF 260KB)
- Trinity Evolution Thaw Guide (PDF 267 KB)
- Trinity Evolution Patient Education Brochure (PDF 792 KB)
Clinical References:
- Rush S. Mesenchymal Stem Cell Allografting in Foot and Ankle Surgery. Foot & Ankle Specialist June 2010 Vol. 3(3):140-147. Full Text Article
- Pountos I, Giannoudis P: Biology of Mesenchymal Stem Cells. Injury 2005 Nov; Vol. 36 Suppl. 3:S8-S12. Full Text Article
- Barry FP, Murphy JM: Mesenchymal Stem Cells: Clinical Applications and Biological Characterization. International Journal of Biochemistry and Cell Biology 2004 Apr; Vol. 36(4):568-84. Full Text Article
- Bonab M et al: Aging of Mesenchymal Stem Cell in Vitro. BMC Cell Biology 2006 Mar 10; Vol. 7:14. Full Text Article
- D'Ippolito G et al: Age-Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow. Journal of Bone and Mineral Research 1999 Jul; Vol. 14(7):1115-22. Full Text Article
- Sethe S et al: Aging of Mesenchymal Stem Cells. Ageing Research Reviews 2006 Feb; Vol. 5(1):91-116. Full Text Article
- Stolzing A et al: Age-Related Changes in Human Bone Marrow-Derived Mesenchymal Stem Cells: Consequences for Cell Therapies. Mechanisms of Ageing and Development 2008 Mar; Vol. 129(3):163-73. Full Text Article
- Le Blanc K et al: HLA Expression and Immunologic Properties of Differentiated and Undifferentiated Mesenchymal Stem Cells. Experimental Hematology 2003 Oct; Vol. 31(10):890-6. Full Text Article
- Ryan JM et al: Mesenchymal Stem Cells Avoid Allogeneic Rejection. Journal of Inflammation (London) 2005 Jul 26; Vol. 2:8. Full Text Article
- Mazur P: Freezing of Living Cells: Mechanisms and Implications. American Journal of Physiology 1984 Sep; Vol. 247(3 Pt 1):C125-42. Full Text Article
Patient Support Materials
- Trinity
Evolution Patient Education Brochure (PDF 792 KB)
Web Resources
Product Description
Trinity® Evolution™ is an allograft of cancellous bone containing viable adult stem cells and osteoprogenitor cells within the matrix and a demineralized bone component. Trinity Evolution offers an ideal alternative to autograft and other bone grafting options (without their drawbacks).
Mesenchymal stem cells (MSCs) are multipotential, capable of responding to their environment to differentiate into a variety of cells as needed. When implanted in patients, MSCs and osteoprogenitor cells do not stimulate an immune response.
Trinity Evolution is processed by the Musculoskeletal Transplant Foundation (MTF), a nonprofit organization dedicated to providing quality tissue. Every step, from donor screening to cryopreservation and pre-release testing, is designed to maximize cell health and ensure patient safety.
Cell health is maximized through donor criteria, processing and vapor-phase liquid nitrogen storage. Improved handling from consistent particle size and specific component ratios ensures quality at every step.